Xarelto 15 mg and 20 mg should be taken with food.
Xarelto 2.5 mg and 10 mg can be taken with or without food.
a Use with caution when patient is concomitantly receiving other medicinal products that increase rivaroxaban plasma concentration.
b Not recommended in patients with CrCl <15 ml/min; use with caution in patients with CrCl 15–29 ml/min and in patients with CrCl 30–49 ml/min when concomitantly receiving other medicinal products that increase rivaroxaban plasma concentration.
c In patients with CrCl 15–49 ml/min 15 mg OD should be considered if the patient’s assessed risk of bleeding outweighs the risk of recurrent PE/DVT.
d In combination with standard antiplatelet therapy of ASA alone or ASA in combination with clopidogrel or ticlopidine, in adults with elevated cardiac biomarkers: Troponin-I/T; creatine kinase-muscle and brain isoenzyme (CK-MB).