Dosing Guide
Prevention of Atherothrombotic Events in patients with Coronary Artery Disease and Peripheral Artery Disease
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Dosage Instructions
Xarelto 15 mg and 20 mg should be taken with food.
Xarelto 2.5 mg and 10 mg can be taken with or without food.
Xarelto oral suspension should be taken with feeding or with food.
* Use with caution in patients with CrCl 15–29 ml/min and in patients with CrCl 30–49 ml/min (2.5 mg, 10 mg) or with kidney dysfunction (15 mg, 20 mg) concomitantly receiving other medicinal products that increase rivaroxaban plasma concentration; not recommended in patients with CrCl <15 ml/min.
† In patients with CrCl 15–49 ml/min, a reduction of the dose from 20 mg OD to 15 mg OD should be considered if the patient’s assessed risk of bleeding outweighs the risk of recurrent PE/DVT.
‡ Use 20 mg OD if at high risk of recurrence: complicated comorbidities or recurrent PE/DVT on extended prevention while on Xarelto 10 mg OD.
§ The weight of the child should be monitored and the dose reviewed regularly, especially for children below 12 kg. This is to ensure that a therapeutic dose is maintained. Dose adjustments should be made based on changes in body weight only.
II No dose adjustment is required in children ≥1 year with mild kidney dysfunction (glomerular filtration rate 50–80 ml/min/1.73 m2); Xarelto is not recommended in children ≥1 year with moderate or severe kidney dysfunction (glomerular filtration rate <50 ml/min/1.73 m2) and in children ≤1 year with serum creatinine results above 97.5th percentile.
¶ 75–100 mg OD.
** ASA alone or ASA plus clopidogrel or ticlopidine. Treatment in combination with other antiplatelet agents, e.g. prasugrel or ticagrelor, has not been studied and is not recommended.
ACS, acute coronary syndrome; ASA, acetylsalicylic acid; BID, twice daily; CrCl, creatinine clearance; DVT, deep vein thrombosis; OD, once daily; PE, pulmonary embolism; TID, three times daily; VTE, venous thromboembolism.
PP-XAR-ALL-1795-2