Pulmonary Embolism │Symptoms

Pulmonary Embolism (PE)

Pulmonary embolism (PE) is a potentially fatal cardiovascular event, responsible for up to 10% of deaths in the hospital.52 The majority of cases of fatal pulmonary embolism (PE), occur in medical (non-surgical, non-trauma) patients.6, 48

Xarelto®, taken as one tablet once daily, was found in clinical studies to be more effective than enoxaparin in preventing venous blood clots that may lead to deep vein thrombosis (DVT) and pulmonary embolism (PE) in adult patients undergoing elective hip or knee replacement surgery.2, 3, 4

Pulmonary Embolism (PE) Symptoms

The first sign of thrombosis may be pulmonary embolism (PE) — a potentially fatal cardiovascular event.52 Therefore, waiting for the signs and symptoms of VTE to appear before instituting anticoagulant treatment increases the risk of morbidity and mortality.
The signs and symptoms of pulmonary embolism (PE) include tachycardia, chest pain, shortness of breath, anxiety, and cough. These symptoms overlap with those for many other cardiac and pulmonary conditions.

  • 52 - Francis CW. Clinical practice. Prophylaxis for thromboembolism in hospitalized medical patients. N Engl J Med. 2007;356(14):1438-1444.
  • 6 - Geerts WH, Bergqvist D, Pineo GF, et al. Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest. 2008;133(6 suppl):381S-453S.
  • 48 - Goldhaber SZ, Tapson VF; DVT FREE Steering Committee. A prospective registry of 5,451 patients with ultrasound-confirmed deep vein thrombosis. Am J Cardiol. 2004;93(2):259-262.
  • 2 - Eriksson BI, Borris LC, Friedman RJ, et al; RECORD1 Study Group. Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty. N Engl J Med. 2008;358(26):2765-2775.
  • 3 - Kakkar AK, Brenner B, Dahl OE, et al; RECORD2 Investigators. Extended duration rivaroxaban versus short-term enoxaparin for the prevention of venous thromboembolism after total hip arthroplasty: a double-blind, randomised controlled trial. Lancet. 2008;372(9632):31-39.
  • 4 - Lassen MR, Ageno W, Borris LC, et al; RECORD3 Investigators. Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty. N Engl J Med. 2008;358(26):2776-2786.